Article
MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice.
Diabetes - 1 Jul 1996
Serreze D V, Gallichan W S, Snider D P, Croitoru K, Rosenthal K L, Leiter E H, Christianson G J, Dudley M E, Roopenian D C
Abstract excerpt
The common class I alleles (e.g., Kd and Db) within the H2g7 major histocompatibility complex (MHC) clearly contribute to autoimmune IDDM in NOD mice, but the mechanism by which this occurs has been controversial. One laboratory has reported that the peptide transporter encoded by the Tap1 gene within H2g7 is defective, and this contributes to IDDM by impairing MHC class I-mediated antigen presentation. If true,...
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