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Article

The Impact of a Single Nucleotide Polymorphism in SIGMAR1 on Depressive Symptoms in Major Depressive Disorder and Bipolar Disorder.

Advances in therapy - 1 Mar 2017

Mandelli Laura, Wang Sheng-Min, Han Changsu, Lee Soo-Jung, Patkar Ashwin A, Masand Prakash S, Pae Chi-Un, Serretti Alessandro

Abstract excerpt

INTRODUCTION: Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive disorder (MDD). We aimed to evaluate the same polymorphism in both MDD and bipolar disorder (BD) as...

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Source

Identifiers

PMID: 28144920
DOI: 10.1007/s12325-017-0482-2

Genes

SIGMAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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