Article
Mutation of the uracil DNA glycosylase gene detected in glioblastoma.
Mutation research - 3 Nov 1998
Moon Y W, Park W S, Vortmeyer A O, Weil R J, Lee Y S, Winters T A, Zhuang Z, Fuller B G
Abstract excerpt
Despite extensive characterization of genetic changes in gliomas, the underlying etiology of these tumors remains largely unknown. Spontaneous DNA damage due to hydrolysis, methylation, and oxidation is a frequent event in the brain. Failure of DNA repair following this damage may contribute to t...
Topics
- Adult
- Aged
- Astrocytoma
- Base Sequence
- Brain Neoplasms
- DNA Glycosylases
- DNA Mutational Analysis
- DNA Primers
- DNA Repair
- DNA, Neoplasm
- Glioblastoma
- Humans
- Middle Aged
- Mutation
- N-Glycosyl Hydrolases
- Oligodendroglioma
- Point Mutation
- Polymerase Chain Reaction