Article
Sequence variation in the human uracil-DNA glycosylase (UNG) gene.
Mutation research - 5 Jan 2001
Kvaløy K, Nilsen H, Steinsbekk K S, Nedal A, Monterotti B, Akbari M, Krokan H E
Abstract excerpt
Spontaneous deamination of cytosine results in a premutagenic G:U mismatch that may result in a GC-->AT transition during replication. The human UNG-gene encodes the major uracil-DNA glycosylase (UDG or UNG) which releases uracil from DNA, thus, initiating base excision repair to restore the correct DNA sequence. Bacterial and yeast mutants lacking the homologous UDG exhibit elevated spontaneous mutation...
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