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Article

A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma.

Neurological research - 1 Dec 2003

Inoue Ryo, Isono Mitsuo, Abe Masako, Abe Tatsuya, Kobayashi Hidenori

Abstract excerpt

Glioblastoma is one of the most malignant tumors in humans. This tumor is thought to develop as a result of the accumulation of genetic abnormalities, mainly focused on the loss of heterozygosity on chromosome 10. O6-methylguanine-DNA methyltransferase (MGMT), which is one of the most important DNA repair proteins, has also been reported that enzymatic activity, as well as the methylation status of the promoter...

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Source

Identifiers

PMID: 14669534
DOI: 10.1179/016164103771954005

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma.PMID 14669534Read ↗

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The MGMT promoter single-nucleotide polymorphism rs1625649 had prognostic impact on patients with MGMT methylated glioblastoma.Semantic proximity Read ↗

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C -> A:T mutations of the TP53 tumor suppressor geneSemantic proximity Read ↗

The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.Semantic proximity Read ↗

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.Semantic proximity Read ↗

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