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Article

Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas.

Acta neuropathologica - 1 Apr 2001

Reis R M, Nakamura M, Masuoka J, Watanabe T, Colella S, Yonekawa Y, Kleihues P, Ohgaki H

Abstract excerpt

Glioblastomas, the most malignant human brain tumors, are characterized by marked aneuploidy, suggesting chromosomal instability which may be caused by a defective mitotic spindle checkpoint. We screened 22 glioblastomas for mutations in the mitotic spindle check-point genes hBUB1, hBUBR1 and hBUB3. DNA sequencing revealed a silent mutation at codon 144 of hBUB1 (CAG-->CAA, Gln-->Gln) in one glioblastoma, a...

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Source

Identifiers

PMID: 11355300
DOI: 10.1007/s004010100366

Genes

CGA
GCA
GCG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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