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Article

Methylation of the p73 gene in gliomas.

Acta neuropathologica - 1 Oct 2002

Watanabe Takao, Huang Huatao, Nakamura Mitsutoshi, Wischhusen Jörg, Weller Michael, Kleihues Paul, Ohgaki Hiroko

Abstract excerpt

The p73 gene encodes a protein structurally and functionally homologous to TP53, and maps to chromosomal band 1p36.33, where loss of heterozygosity has been observed in up to 90% of oligodendrogliomas and in 10-25% of diffuse astrocytomas. We assessed the methylation status of the CpG islands in the promoter region of the p73 gene by methylation-specific PCR in 117 glioma biopsies. Methylation was detected in 5...

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Source

Identifiers

PMID: 12200621
DOI: 10.1007/s00401-002-0549-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation of the p73 gene in gliomas.PMID 12200621Read ↗

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