Article
Mutations of the p16 gene in gliomas.
Oncogene - 4 Jan 1996
Kyritsis A P, Zhang B, Zhang W, Xiao M, Takeshima H, Bondy M L, Cunningham J E, Levin V A, Bruner J
Abstract excerpt
In the present study we investigated the frequency of p16 gene exon 2 mutations in 35 malignant gliomas, using either direct sequencing of the PCR products or cloning into the pCRII vector and sequencing of the cloned PCR products. No mutations were detected during direct sequencing of the PCR products. However, after sequencing of individual clones, we found multiple mutations in 5 tumors involving codons 73(GCC...
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