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Article

Alterations in tumour suppressor gene p53 in human gliomas from Indian patients.

Journal of biosciences - 1 Dec 2002

Phatak Poornima, Selvi S Kalai, Divya T, Hegde A S, Hegde Sridevi, Somasundaram Kumaravel

Abstract excerpt

Alterations in tumour suppressor p53 gene are the most common defects seen in a variety of human cancers. In order to study the significance of the p53 gene in the genesis and development of human glioma from Indian patients, we checked 44 untreated primary gliomas for mutations in exons 5-9 of the p53 gene by PCR-SSCP and DNA sequencing. Sequencing analysis revealed six missense mutations. The incidence of p53...

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Identifiers

PMID: 12571372
DOI: 10.1007/BF02708375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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