Article
High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations.
Cancer genetics and cytogenetics - 15 Jan 2009
Jesien-Lewandowicz Emilia, Jesionek-Kupnicka Dorota, Zawlik Izabela, Szybka Małgorzata, Kulczycka-Wojdala Dominika, Rieske Piotr, Sieruta Monika, Jaskolski Dariusz, Och Waldemar, Skowronski Wiesław, Sikorska Beata, Potemski Piotr, Papierz Wielislaw, Liberski Pawel P, Kordek Radzisław
Abstract excerpt
O(6)-methylguanine DNA methyltransferase (MGMT) reduces cytotoxicity of therapeutic or environmental alkylating agents. MGMT promoter methylation has been associated with TP53 G: C to A:T transition mutations in various types of cancers, and with poor prognosis in patients who did not receive chemotherapy. Mutations of TP53 are more frequent in secondary than in primary glioblastoma, thus the expected MGMT...
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