Article
Repression of the minimal HLA-B promoter by c-myc and p53 occurs through independent mechanisms.
Molecular immunology - 1 Sept 1998
Griffioen M, Steegenga W T, Ouwerkerk I J, Peltenburg L T, Jochemsen A G, Schrier P I
Abstract excerpt
Major Histocompatibility Complex (MHC, HLA in humans) class I antigens play an important role in cellular immunology by presenting antigens to T cells. Downregulation of MHC class I expression is thought to be a mechanism by which tumor cells escape from T cell-mediated lysis. In primary human me...
Topics
- Binding Sites
- Cell Line
- Down-Regulation
- Genes, MHC Class I
- Genes, Reporter
- Genes, myc
- Genes, p53
- HLA-B Antigens
- HLA-B7 Antigen
- Humans
- Luciferases
- Mutation
- Promoter Regions, Genetic
- Protein Binding
- Proto-Oncogene Proteins c-myc
- Transfection
- Tumor Suppressor Protein p53