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Article

Repression of the minimal HLA-B promoter by c-myc and p53 occurs through independent mechanisms.

Molecular immunology - 1 Sept 1998

Griffioen M, Steegenga W T, Ouwerkerk I J, Peltenburg L T, Jochemsen A G, Schrier P I

Abstract excerpt

Major Histocompatibility Complex (MHC, HLA in humans) class I antigens play an important role in cellular immunology by presenting antigens to T cells. Downregulation of MHC class I expression is thought to be a mechanism by which tumor cells escape from T cell-mediated lysis. In primary human melanomas and melanoma cell lines, HLA-B expression is frequently downmodulated, correlating with elevated expression of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9839551
DOI: 10.1016/s0161-5890(98)00074-1

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TCTA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Repression of the minimal HLA-B promoter by c-myc and p53 occurs through independent mechanisms.PMID 9839551Read ↗

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