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Article

Repression of c-myc is necessary but not sufficient for terminal differentiation of B lymphocytes in vitro.

Molecular and cellular biology - 1 Dec 2000

Lin K I, Lin Y, Calame K

Abstract excerpt

The importance of c-myc as a target of the Blimp-1 repressor has been studied in BCL-1 cells, in which Blimp-1 is sufficient to trigger terminal B-cell differentiation. Our data show that Blimp-1-dependent repression of c-myc is required for BCL-1 differentiation, since constitutive expression of c-Myc blocked differentiation. Furthermore, ectopic expression of cyclin E mimicked the effects of c-Myc on both...

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Share to B-Lymphocytes
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Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11073970
DOI: 10.1128/MCB.20.23.8684-8695.2000
PMCID: PMC86481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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