Article
Decreased intraindividual HLA class I expression is due to reduced transcription in advanced melanoma and does not correlate with HLA-G expression.
The Journal of investigative dermatology - 1 Dec 2001
Willers J, Urosevic M, Laine E, Geertsen R, Kündig T, Burg G, Dummer R
Abstract excerpt
The presentation of endogenously synthesized peptides in association with HLA class I molecules allows the activation of CD8(+) lymphocytes. Tumor cells often fail to present antigenic peptides resulting in the immune escape of metastasizing cells. The aim of this study was to elucidate possible molecular mechanisms leading to reduced antigen presentation in melanoma. Melanoma cell short-time cultures were...
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