Article
A novel strategy of c-myc oncogene in NK activity regulation not related to the W6/32 MHC class-I epitope.
International journal of cancer - 1 Jul 1994
La Cava A, Carbone E, Moscarella A, Barcová M, Salzano S, Zappacosta S, Fontana S
Abstract excerpt
The c-myc gene encodes a nuclear protein whose precise function is still not fully understood. Introduction of a c-myc gene into a number of cell lines leads to an increase in their susceptibility to NK-cell lysis. It was reported earlier that c-myc can induce a decrease in the membrane expression of the MHC class-I molecules and this may be one of the factors that render target cells relatively more susceptible...
Topics
- Animals
- Antigens, Surface
- Blotting, Northern
- Callithrix
- Cell Adhesion Molecules
- Cell Transformation, Viral
- Cold Temperature
- Cytotoxicity, Immunologic
- Epitopes
- Gene Expression
- Genes, myc