Article
The tumour suppressor protein p53 can repress transcription of cyclin B.
Nucleic acids research - 15 Nov 2000
Krause K, Wasner M, Reinhard W, Haugwitz U, Dohna C L, Mössner J, Engeland K
Abstract excerpt
The tumour suppressor protein p53 has functions in controlling the G(1)/S and G(2)/M transitions. Central regulators for progression from G(2) to mitosis are B-type cyclins complexed with cdc2 kinase. In mammals two cyclin B proteins are found, cyclin B1 and B2. We show that upon treatment of HepG2 cells with 5-fluorouracil or methotrexate, p53 levels increase while concentrations of cyclin B2 mRNA, measured by...
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