Article
Repression of class II major histocompatibility complex genes by cyclic AMP is mediated by conserved promoter elements.
The Journal of experimental medicine - 1 Dec 1991
Ivashkiv L B, Glimcher L H
Abstract excerpt
The induction of cell surface expression of class II major histocompatibility complex (MHC) antigens by interleukin (IL)-4 and interferon (IFN)-gamma is inhibited by elevation of intracellular cyclic (c)AMP, which is caused by immunomodulatory agents such as E series prostaglandins (PGEs). To inv...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Base Sequence
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Cyclic AMP
- Genes, MHC Class II
- Histocompatibility Antigens Class II
- Interferon-gamma
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Protein Kinases
- RNA, Messenger