The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.

doi:10.1101/gad.4.1.75

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Article

The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.

Genes & development - 1 Jan 1990

Spencer C A, LeStrange R C, Novak U, Hayward W S, Groudine M

Abstract excerpt

Aberrant c-myc expression patterns occur in human Burkitt's lymphoma cells, which consistently exhibit c-myc chromosomal translocations, mutations within and flanking the translocated allele, a loss of the block to transcription elongation in exon 1, and a promoter shift to use of the upstream P1...

Topics

Alleles
Animals
Blotting, Northern
Burkitt Lymphoma
Cell Line
Humans
Mice
Oocytes
Promoter Regions, Genetic
Proto-Oncogenes
Restriction Mapping
Transcription, Genetic
Transfection
Tumor Cells, Cultured
Xenopus

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