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Article

The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.

Genes & development - 1 Jan 1990

Spencer C A, LeStrange R C, Novak U, Hayward W S, Groudine M

Abstract excerpt

Aberrant c-myc expression patterns occur in human Burkitt's lymphoma cells, which consistently exhibit c-myc chromosomal translocations, mutations within and flanking the translocated allele, a loss of the block to transcription elongation in exon 1, and a promoter shift to use of the upstream P1 promoter. To define the mechanism responsible for the loss of transcription elongation blockage and resulting c-myc...

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Identifiers

PMID: 2307371
DOI: 10.1101/gad.4.1.75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.PMID 2307371Read ↗

Molecular analysis of the c-myc transcription elongation block. Implications for the generation of Burkitt's lymphoma.Semantic proximity Read ↗

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Differential regulation of the c-MYC P1 and P2 promoters in the absence of functional tumor suppressors: implications for mechanisms of deregulated MYC transcription.Semantic proximity Read ↗

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