Wild-type operator binding and altered cooperativity for inducer binding of lac repressor dimer mutant R3.

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Article

Wild-type operator binding and altered cooperativity for inducer binding of lac repressor dimer mutant R3.

The Journal of biological chemistry - 29 Apr 1994

Chen J, Alberti S, Matthews K S

Abstract excerpt

Substitution of the C-terminal leucine heptad repeat region of the normally tetrameric lactose repressor by the leucine heptad repeat dimerization domain of GCN4 protein resulted in cell extracts containing protein, designated R3, which behaved as a dimer based on gel retardation analysis of DNA...

Topics

Allosteric Regulation
Amino Acid Sequence
Antibodies, Monoclonal
Base Sequence
Binding Sites
DNA, Bacterial
Escherichia coli
Isopropyl Thiogalactoside
Molecular Sequence Data
Mutation
Operator Regions, Genetic
Repressor Proteins

Source

Open in PubMed

Identifiers

PMID: 8175655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8175655-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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