Article
Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.
Biochemistry - 15 Jan 2002
Huffman Joy L, Lu Fu, Zalkin Howard, Brennan Richard G
Abstract excerpt
The crystal structures of corepressor-bound and free Escherichia coli purine repressor (PurR) have delineated the roles of several residues in corepressor binding and specificity and the intramolecular signal transduction (allosterism) of this LacI/GalR family member. From these structures, residue W147 was implicated as a key component of the allosteric response, but in many members of the LacI/GalR family,...
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