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Article

Operator search by mutant Lac repressors.

Journal of molecular biology - 8 May 1998

Barker A, Fickert R, Oehler S, Müller-hill B

Abstract excerpt

The Escherichia coli Lac and Gal repressors are two members of a large family of bacterial repressor proteins that share significant sequence and structural homology. Efficient repression by all family members requires specific binding to a site or sites close to the transcriptional start of the genes regulated. Both LacR and GalR have to bind to at least two sites for efficient repression, yet they differ in one...

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Identifiers

PMID: 9600838
DOI: 10.1006/jmbi.1998.1729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Operator search by mutant Lac repressors.PMID 9600838Read ↗

Mutant lac repressors with new specificities hint at rules for protein--DNA recognition.Semantic proximity Read ↗

Functional rules for lac repressor-operator associations and implications for protein-DNA interactions.Semantic proximity Read ↗

Evolving Lac repressor for enhanced inducibility.Semantic proximity Read ↗

Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.Semantic proximity Read ↗

Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions.Semantic proximity Read ↗

Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding.Semantic proximity Read ↗

Wild-type operator binding and altered cooperativity for inducer binding of lac repressor dimer mutant R3.Semantic proximity Read ↗

Engineering allostery.Semantic proximity Read ↗

DNA-binding properties of a lac repressor mutant incapable of forming tetramers.Semantic proximity Read ↗

Operator DNA sequence variation enhances high affinity binding by hinge helix mutants of lactose repressor protein.Semantic proximity Read ↗

The non-inducible nature of super-repressors of the gal operon in Escherichia coli.Semantic proximity Read ↗

Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.Semantic proximity Read ↗

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