Article
Somatic mutation in the neonatal mouse.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1998
Giorgetti C A, Press J L
Abstract excerpt
Several mechanisms that diversify the adult immune repertoire, such as terminal deoxynucleotidyl transferase-dependent N region addition, are not available to the neonatal mouse. One important process that contributes to protective immunity in the adult is somatic mutation, which plays a major ro...
Topics
- Animals
- Animals, Newborn
- Base Sequence
- Chickens
- Female
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Male
- Mice
- Mice, Inbred BALB C
