Article
Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1997
Wloch M K, Alexander A L, Pippen A M, Pisetsky D S, Gilkeson G S
Abstract excerpt
To elucidate the mechanism of Ag drive in the anti-DNA response, the Ab response to bacterial DNA has been analyzed in normal and autoimmune mice. Preautoimmune NZB/W mice immunized with Escherichia coli dsDNA produce Abs that resemble spontaneous autoantibodies and bind mammalian dsDNA. In contrast, normal mice, when immunized similarly, produce Abs that bind only bacterial dsDNA. To characterize further the...
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