Article
Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 1997
Wloch M K, Alexander A L, Pippen A M, Pisetsky D S, Gilkeson G S
Abstract excerpt
To elucidate the mechanism of Ag drive in the anti-DNA response, the Ab response to bacterial DNA has been analyzed in normal and autoimmune mice. Preautoimmune NZB/W mice immunized with Escherichia coli dsDNA produce Abs that resemble spontaneous autoantibodies and bind mammalian dsDNA. In contr...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Antinuclear
- Arginine
- Autoimmunity
- B-Lymphocytes
- Base Sequence
- DNA, Bacterial
- Escherichia coli
- Female
- Genes, Immunoglobulin
- Mice
- Mice, Inbred NZB
- Molecular Sequence Data
- Mutation