Article
Somatic mutation in constant regions of mouse lambda 1 light chains.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1991
Motoyama N, Okada H, Azuma T
Abstract excerpt
To study the distribution of somatic mutation, we determined nucleotide sequences of rearranged lambda 1-chain genomic DNA from four hybridomas obtained from C57BL/6 mice that had been immunized with (4-hydroxy-3-nitrophenyl)acetyl-conjugated chicken gamma globulin. In total, 114 nucleotide subst...
Topics
- Animals
- Antibody Diversity
- Base Sequence
- Cloning, Molecular
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Immunoglobulin Constant Regions
- Immunoglobulin lambda-Chains
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Polymerase Chain Reaction