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Article

Cadherin and catenin alterations in human cancer.

Genes, chromosomes & cancer - 1 Jul 2002

Hajra Karen M, Fearon Eric R

Abstract excerpt

Among the hallmarks of cancer are defective cell-cell and cell-matrix adhesion. Alterations in cadherin-catenin complexes likely have a major contributing role in cell-adhesion defects in carcinomas arising in many different tissues. E-cadherin, the prototypic member of the cadherin transmembrane protein family, regulates cell adhesion by interacting with E-cadherin molecules on opposing cell surfaces....

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PMID: 12007186
DOI: 10.1002/gcc.10083

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