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Article

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.

Molecular and cellular biology - 1 Mar 1995

Kawanishi J, Kato J, Sasaki K, Fujii S, Watanabe N, Niitsu Y

Abstract excerpt

Detachment of cell-cell adhesion is indispensable for the first step of invasion and metastasis of cancer. This mechanism is frequently associated with the impairment of either E-cadherin expression or function. However, mechanisms of such abnormalities have not been fully elucidated. In this study, we demonstrated that the function of E-cadherin was completely abolished in the human gastric cancer cell line...

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Identifiers

PMID: 7862112
DOI: 10.1128/MCB.15.3.1175
PMCID: PMC230340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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