Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.

doi:10.1128/MCB.15.3.1175

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Article

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.

Molecular and cellular biology - 1 Mar 1995

Kawanishi J, Kato J, Sasaki K, Fujii S, Watanabe N, Niitsu Y

Abstract excerpt

Detachment of cell-cell adhesion is indispensable for the first step of invasion and metastasis of cancer. This mechanism is frequently associated with the impairment of either E-cadherin expression or function. However, mechanisms of such abnormalities have not been fully elucidated. In this study, we demonstrated that the function of E-cadherin was completely abolished in the human gastric cancer cell line...

Topics

Antibodies, Monoclonal
Base Sequence
Blotting, Western
Cadherins
Cell Adhesion
Cell Aggregation
Cell Line
Cytoskeletal Proteins
DNA Primers
DNA, Complementary
Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

RNA, Messenger

Recombinant Proteins

Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 7862112
DOI: 10.1128/MCB.15.3.1175
PMCID: PMC230340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7862112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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