Article
αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.
The Journal of pathology - 1 Aug 2018
de Groot Jolien S, Ratze Max Ak, van Amersfoort Miranda, Eisemann Tanja, Vlug Eva J, Niklaas Mijanou T, Chin Suet-Feung, Caldas Carlos, van Diest Paul J, Jonkers Jos, de Rooij Johan, Derksen Patrick Wb
Abstract excerpt
Although mutational inactivation of E-cadherin (CDH1) is the main driver of invasive lobular breast cancer (ILC), approximately 10-15% of all ILCs retain membrane-localized E-cadherin despite the presence of an apparent non-cohesive and invasive lobular growth pattern. Given that ILC is dependent on constitutive actomyosin contraction for tumor development and progression, we used a combination of cell systems...
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