Deranged expression of the E‐cadherin/β‐catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas

Abstract excerpt

BACKGROUND: Deranged expression and function of the E-cadherin/beta-catenin (E-cad/beta-cat) complex and the epidermal growth factor receptor (EGFR) have been implicated in the development and progression of carcinomas. METHODS: To estimate the role of these molecules in oral cancer, we investigated 75 primary oral squamous cell carcinomas (OSCCs) with adjacent normal and/or dysplastic mucosa, 30 paired...

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