Article
Genotyping metabolic polymorphisms in a cohort of Caucasians and single strand conformation polymorphism analysis of point mutations in human hprt exons 7 and 8.
Electrophoresis - 1 Oct 1998
Krause G, Garganta F, Kosytorz P, Scherer G
Abstract excerpt
In genetic toxicology, the main fields of applications of the polymerase chain reaction (PCR) with subsequent electrophoretic characterization of amplificates include genotyping polymorphisms in the xenobiotic metabolism and mutant analysis. To assess the role of the individual sets of biotransfo...
Topics
- Aryl Hydrocarbon Hydroxylases
- Arylamine N-Acetyltransferase
- Base Sequence
- Cohort Studies
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP2A6
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Electrophoresis, Agar Gel
- Exons
- Genotype
- Glutathione Transferase
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mixed Function Oxygenases
- Molecular Sequence Data
- Nucleic Acid Conformation
- Point Mutation