Article
Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique.
European journal of human genetics : EJHG - 1 Sept 2006
Nasedkina Tatyana V, Fedorova Olga E, Glotov Andrei S, Chupova Natalia V, Samochatova Elena V, Maiorova Olga A, Zemlyakova Valeria V, Roudneva Anastasia E, Chudinov Alexander V, Yurasov Roman A, Kozhekbaeva Janna M, Barsky Victor E, Krynetskiy Eugene Y, Krynetskaia Natalia F, Cheng Cheng, Ribeiro Raul C, Evans William E, Roumyantsev Alexander G, Zasedatelev Alexander S
Abstract excerpt
Thiopurine drugs are metabolized, in part, by S-methylation catalyzed by thiopurine S-methyltransferase (TPMT). Patients with very low or undetectable TPMT activity are at high risk of severe, potentially fatal hematopoietic toxicity when they are treated with standard doses of thiopurines. As human TPMT activity is controlled by a common genetic polymorphism, it is an excellent candidate for the clinical...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.