Article
Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population.
European journal of clinical pharmacology - 1 Aug 2003
Gaikovitch Elena A, Cascorbi Ingolf, Mrozikiewicz Przemyslaw M, Brockmöller Jürgen, Frötschl Roland, Köpke Karla, Gerloff Thomas, Chernov Jury N, Roots Ivar
Abstract excerpt
OBJECTIVE: The frequency of functionally important mutations and alleles of genes coding for xenobiotic metabolizing enzymes shows a wide ethnic variation. However, little is known of the frequency distribution of the major allelic variants in the Russian population. METHODS: Using polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) genotyping assays and the real-time PCR with...
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