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Article

A Method to Determine Xenobiotic Acetylation Rate by Taq SNP rs1495741.

Bulletin of experimental biology and medicine - 1 Aug 2022

Ogarkov O B, Peretolchina N P, Malov S I, Orlova E A, Stepanenko L A, Khromova P A, Malov I V, Kolesnikov S I

Abstract excerpt

Drug acetylation plays an important role in the medical practice. Modern methods of acetylation phenotype prediction are based on genotyping of polymorphisms in the second exon of the gene NAT2. Some disadvantages of these methods limit their application in the clinical practice. We developed a method of human genotyping based on identification of NAT2 gene polymorphism rs1495741 by real-time PCR. This method of...

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PMID: 36058971
DOI: 10.1007/s10517-022-05572-6

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