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Article

Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice.

Developmental immunology - 1 Jan 1998

Reya T, Bassiri H, Biancaniello R, Carding S R

Abstract excerpt

The role that interleukin-2 (IL-2) plays in T-cell development is not known. To address this issue, we have investigated the nature of the abnormal thymic development and autoimmune disorders that occurs in IL-2-deficient (IL-2-/-) mice. After 4 to 5 weeks of birth, IL-2-/- mice progressively dev...

Topics

Animals
Autoimmune Diseases
Cell Differentiation
Cell Transplantation
Germ-Free Life
Hematopoietic Stem Cells
Interleukin-2
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Phenotype
Stromal Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 9814585
DOI: 10.1155/1998/19567
PMCID: PMC2275991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9814585-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice.PMID 9814585Read ↗

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