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Article

Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice.

Developmental immunology - 1 Jan 1998

Reya T, Bassiri H, Biancaniello R, Carding S R

Abstract excerpt

The role that interleukin-2 (IL-2) plays in T-cell development is not known. To address this issue, we have investigated the nature of the abnormal thymic development and autoimmune disorders that occurs in IL-2-deficient (IL-2-/-) mice. After 4 to 5 weeks of birth, IL-2-/- mice progressively develop a thymic disorder resulting in the disruption of thymocyte maturation. This disorder is characterized by a...

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Identifiers

PMID: 9814585
DOI: 10.1155/1998/19567
PMCID: PMC2275991

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