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Article

Interleukin 4 expressed in situ selectively alters thymocyte development.

The Journal of experimental medicine - 1 Jan 1991

Lewis D B, Yu C C, Forbush K A, Carpenter J, Sato T A, Grossman A, Liggitt D H, Perlmutter R M

Abstract excerpt

Using a transgenic mouse model we show that increased intrathymic expression of interleukin 4 (IL-4) significantly perturbs the development of thymocytes. Transgenic double-positive (CD4+CD8+) thymocytes, which are present in dramatically reduced numbers, exhibit increased T cell receptor (TCR) expression and increased mobilization of calcium mediated by these receptors. In contrast, transgenic single-positive...

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Identifiers

PMID: 1824637
DOI: 10.1084/jem.173.1.89
PMCID: PMC2118750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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