Article
Interleukin 4 expressed in situ selectively alters thymocyte development.
The Journal of experimental medicine - 1 Jan 1991
Lewis D B, Yu C C, Forbush K A, Carpenter J, Sato T A, Grossman A, Liggitt D H, Perlmutter R M
Abstract excerpt
Using a transgenic mouse model we show that increased intrathymic expression of interleukin 4 (IL-4) significantly perturbs the development of thymocytes. Transgenic double-positive (CD4+CD8+) thymocytes, which are present in dramatically reduced numbers, exhibit increased T cell receptor (TCR) expression and increased mobilization of calcium mediated by these receptors. In contrast, transgenic single-positive...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- B-Lymphocytes
- CD4 Antigens
- CD8 Antigens
- Immunoglobulin Isotypes
- Interleukin-4
- Lymphocyte Activation
- Mast Cells
- Mice