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Article

Mutant IL-2-expressing mesenchymal stromal cells promote regulatory T cells proliferation and activation in collagen induced arthritis mice.

Arthritis research & therapy - 8 Dec 2025

Tang Zhicheng, Yang Fan, Shen Jingyi, Wu Haolin, Hong Huiming, Wang Yue, Yin Fanzhang, Tang Xiaojun, Zhang Huayong

Abstract excerpt

OBJECTIVES: Research indicates that low doses of interleukin-2 (IL-2) can effectively mitigate Rheumatoid arthritis (RA) symptoms by promoting Treg cells, while high doses may enhance immune responses and exacerbate the disease. Consequently, this study employed mutated IL-2 to minimize its impact on CD8+ T and NK cell activation while preserving its influence on Treg cells. METHODS: We used a previously...

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Identifiers

PMID: 41361892
DOI: 10.1186/s13075-025-03623-7
PMCID: PMC12797657

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MSC

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