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Article

Transforming growth factor-beta2 is involved in quantitative genetic variation in thymic involution.

Blood - 1 Mar 2006

Kumar Ritu, Langer Jessica C, Snoeck Hans-Willem

Abstract excerpt

The mechanisms regulating thymic involution are unclear. In inbred mouse strains the rate of thymic involution and the function of the hematopoietic stem cell (HSC) compartment are subject to quantitative genetic variation. We have shown previously that transforming growth factor-beta2 (TGF-beta2) is a genetically determined positive regulator of HSCs. Here, we demonstrate that genetic variation in the rate of...

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Identifiers

PMID: 16282338
DOI: 10.1182/blood-2005-04-1495
PMCID: PMC1895709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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