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Article

Hematopoietic stem cell functional failure in interleukin-2-deficient mice.

Journal of hematotherapy & stem cell research - 1 Dec 2002

Chen J, Astle C M, Harrison D E

Abstract excerpt

The effects of interleukin-2 (IL-2) deficiency on hematopoiesis were tested by measuring cellular compositions in peripheral blood, spleen, thymus, and bone marrow of 3- to 5-month-old gene-targeted Il2 null (Il2(-/-)) mice using the Advia 120 Hematology system and fluorescence-activated cell staining (FACS). Il2(-/-) mice developed hematological failure and autoimmune responses, showing variable but significant...

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Identifiers

PMID: 12590705
DOI: 10.1089/152581602321080565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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