Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development

15 May 1999

Abstract excerpt

Prostaglandin G and H synthases, or cyclooxygenases (COXs), catalyze the formation of prostaglandins (PGs). Whereas COX-1 is diffusely expressed in lymphoid cells in embryonic day 15.5 thymus, COX-2 expression is sparse, apparently limited to stromal cells. By contrast, COX-2 is predominant in a subset of medullary stromal cells in three- to five-week-old mice. The isozymes also differ in their contributions to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to Estrogen and related hormone effects
Share to Inflammatory mediators and NSAID effects

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10330429
DOI: 10.1172/jci6400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct roles of prostaglandin H synthases 1 and 2 in T-cell developmentPMID 10330429Read ↗

Distinct expression of cyclooxygenase-1 and -2 in the human thymus.Semantic proximity Read ↗

Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.Semantic proximity Read ↗

Distinct functions of COX-1 and COX-2.Semantic proximity Read ↗

Cyclooxygenase and prostaglandins in somatic cell populations of the testisSemantic proximity Read ↗

<i>De novo</i> steroidogenesis maintains female-specific Th2 identity and constrains effector functionSemantic proximity Read ↗

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.Semantic proximity Read ↗

Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis.Semantic proximity Read ↗

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.Semantic proximity Read ↗

The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development.Semantic proximity Read ↗

An Analysis of T Cell Intrinsic Roles of E2A by Conditional Gene Disruption in the ThymusSemantic proximity Read ↗

Embryonic prostaglandin H synthase-2 (PHS-2) expression and benzo[a]pyrene teratogenicity in PHS-2 knockout mice.Semantic proximity Read ↗

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.