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Article

Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines.

The Journal of pharmacology and experimental therapeutics - 1 Nov 1998

Shen E H, Dorow J, Harland R, Burkhart-Kasch S, Phillips T J

Abstract excerpt

FAST and SLOW selected mouse lines were bred for differences in locomotor response to low-dose ethanol. FAST mice exhibit an extreme stimulant response and SLOW mice exhibit locomotor depression at the same ethanol dose. We tested the hypothesis that gamma-aminobutyric acid (GABA) systems modulate ethanol's stimulant effects by examining convulsant responses to GABAA receptor ligands, and by assessing the effects...

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Source

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PMID: 9808687

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