Article
Bidirectional selective breeding for ethanol effects on locomotor activity: characterization of FAST and SLOW mice through selection generation 35.
Alcoholism, clinical and experimental research - 1 Oct 1995
Shen E H, Harland R D, Crabbe J C, Phillips T J
Abstract excerpt
Increased recognition of the advantages of genetic animal models has led to heightened interest in their use and development. A replicated bidirectional selective breeding project has produced lines of mice that differ in their locomotor responses to 2.0 g/kg ethanol. FAST-1 and FAST-2 mice are h...
Topics
- Alcohol Drinking
- Alcoholism
- Animals
- Arousal
- Dose-Response Relationship, Drug
- Ethanol
- Female
- Male
- Mice
- Mice, Inbred Strains
- Models, Genetic
- Motor Activity
- Phenotype
- Reaction Time
- Selection, Genetic