Article
Ethanol-induced activation and rapid development of tolerance may have some underlying genes in common.
Genes, brain, and behavior - 1 May 2002
Ponomarev I, Crabbe J C
Abstract excerpt
Ethanol exerts biphasic effects on behavior, stimulant at low doses and depressant at higher doses. In the present study we used two mouse genetic models to investigate the relationships among activating and depressant responses to alcohol. The first model was a panel of nine isogenic genotypes. FAST and SLOW mice, selectively bred for high and low ethanol-induced motor activation, respectively, were used as a...
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