Article
Response to selection for ethanol-induced locomotor activation: genetic analyses and selection response characterization.
Psychopharmacology - 1 Jan 1991
Phillips T J, Burkhart-Kasch S, Terdal E S, Crabbe J C
Abstract excerpt
Selectively bred FAST mice are highly susceptible, while SLOW mice are less susceptible, to the locomotor stimulant effects of ethanol. Heritability estimates indicate that approximately 15% of the variance in the FAST lines is of additive genetic origin, while low susceptibility is ostensibly no...
Topics
- Animals
- Dose-Response Relationship, Drug
- Ethanol
- Female
- Habituation, Psychophysiologic
- Injections, Intravenous
- Male
- Mice
- Motor Activity
- Phenotype