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Article

gamma-Aminobutyric acid-activated chloride channels in rats selectively bred for differential acute sensitivity to alcohol.

Alcoholism, clinical and experimental research - 1 Mar 1991

Allan A M, Mayes G G, Draski L J

Abstract excerpt

Effects of various sedative hypnotic agents on GABA-mediated chloride flux were evaluated in whole brain membrane vesicles (microsacs) prepared from rats selectively bred for high (HAS) and low sensitivity (LAS) to an acute hypnotic dose of alcohol. The HAS rats were more sensitive to the effects of pentobarbital, phenobarbital, flunitrazepam, and ethanol on GABA-mediated chloride flux compared with the LAS rats....

Topics

Alcohol Drinking
Animals
Chloride Channels
Diazepam
Female
Flunitrazepam
Membrane Proteins
Muscimol
Pentobarbital
Phenobarbital
Phenotype
Picrotoxin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred Strains

Receptors, GABA-A

Selection, Genetic

gamma-Aminobutyric Acid

Source

Identifiers

PMID: 1647704
DOI: 10.1111/j.1530-0277.1991.tb01858.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1647704-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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