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Article

Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.

Addiction biology - 1 Jan 2010

Blednov Yuri A, Walker Danielle L, Iyer Sangeetha V, Homanics Gregg, Harris Adron R

Abstract excerpt

Gamma-aminobutyric acid (GABA) is synthesized in brain by two isoforms of glutamic acid decarboxylase (Gad), Gad1 and Gad2. Gad1 provides most of the GABA in brain, but Gad2 can be rapidly activated in times of high GABA demand. Mice lacking Gad2 are viable whereas deletion of Gad1 is lethal. We produced null mutant mice for Gad2 on three different genetic backgrounds: predominantly C57BL/6J and one or two...

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Identifiers

PMID: 20002022
DOI: 10.1111/j.1369-1600.2009.00186.x
PMCID: PMC3038569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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