Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Use of a novel mouse genotype to model acute benzodiazepine withdrawal.

Behavior genetics - 1 Jan 2007

Metten Pamela, Buck Kari J, Merrill Catherine M, Roberts Amanda J, Yu Chia-Hua, Crabbe John C

Abstract excerpt

Withdrawal from benzodiazepines in physically dependent rodents often requires that the drug be dislodged from its receptor with a competitive antagonist. Withdrawal Seizure-Prone (WSP) mice were selectively bred for their susceptibility to handling-induced withdrawal convulsions following chronic treatment with ethanol. Reflecting pleiotropic genetic influences, they also experience more severe withdrawal from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Anxiety Agents
Share to Benzodiazepines
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Receptors, GABA-A

Share to Seizures

Share to Substance Withdrawal Syndrome

Share to Time Factors

Source

Identifiers

PMID: 17226103
DOI: 10.1007/s10519-006-9094-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Use of a novel mouse genotype to model acute benzodiazepine withdrawal.PMID 17226103Read ↗

Indexing withdrawal in mice: matching genotypes for exposure in studies using ethanol vapor inhalation.Semantic proximity Read ↗

Chronic ethanol differentially alters susceptibility to chemically induced convulsions in withdrawal seizure-prone and -resistant mice.Semantic proximity Read ↗

Genetic and pharmacological manipulations of glyoxalase 1 mediate ethanol withdrawal seizure susceptibility in miceSemantic proximity Read ↗

Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines.Semantic proximity Read ↗

Anxiety and sensitivity to ethanol and pentobarbital in alcohol withdrawal seizure-prone and withdrawal seizure-resistant mice.Semantic proximity Read ↗

Motor impairment: a new ethanol withdrawal phenotype in mice.Semantic proximity Read ↗

Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.Semantic proximity Read ↗

Selective breeding for alcohol withdrawal severity.Semantic proximity Read ↗

Regulation of operant ethanol-reinforced behavior is genetically independent of regulation of withdrawal severity in WSP and WSR mice.Semantic proximity Read ↗

Ethanol tolerance and withdrawal responses in GABA(A) receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice.Semantic proximity Read ↗

Examining opioid withdrawal scoring and adaptation of global scoring systems to male and female C57BL/6J miceSemantic proximity Read ↗

Biological sex influences sleep phenotype in mice experiencing spontaneous opioid withdrawal.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.