Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.

doi:10.1101/gad.12.21.3337

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Article

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.

Genes & development - 1 Nov 1998

Nolan K M, Barrett K, Lu Y, Hu K Q, Vincent S, Settleman J

Abstract excerpt

The Rac and Cdc42 GTPases share several regulators and effectors, yet perform distinct biological functions. The factors determining such specificity in vivo have not been identified. In a mutational screen in Drosophila to identify Rac-specific signaling components, we isolated 11 alleles of myo...

Topics

Animals
Animals, Genetically Modified
COS Cells
Caenorhabditis elegans Proteins
Cytoskeletal Proteins
Drosophila
Drosophila Proteins
GTP Phosphohydrolases
GTP-Binding Proteins
Gene Expression Regulation, Developmental
Insect Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mutation

Proteins

Sequence Homology, Amino Acid

Signal Transduction

rac GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9808621
DOI: 10.1101/gad.12.21.3337
PMCID: PMC317223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9808621-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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