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Article

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.

Genes & development - 1 Nov 1998

Nolan K M, Barrett K, Lu Y, Hu K Q, Vincent S, Settleman J

Abstract excerpt

The Rac and Cdc42 GTPases share several regulators and effectors, yet perform distinct biological functions. The factors determining such specificity in vivo have not been identified. In a mutational screen in Drosophila to identify Rac-specific signaling components, we isolated 11 alleles of myoblast city (mbc). mbc mutant embryos exhibit defects in dorsal closure, myogenesis, and neural development. DOCK180,...

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Identifiers

PMID: 9808621
DOI: 10.1101/gad.12.21.3337
PMCID: PMC317223

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