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Article

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2008

Laurin Mélanie, Fradet Nadine, Blangy Anne, Hall Alan, Vuori Kristiina, Côté Jean-François

Abstract excerpt

Dock1 (also known as Dock180) is a prototypical member of a new family of atypical Rho GTPase activators. Genetic studies in Drosophila and Caenorhabditis elegans have demonstrated that Dock1 orthologues in these organisms have a crucial role in activating Rac GTPase signaling. We generated mutant alleles of the closely related Dock1 and Dock5 genes to study their function in mammals. We report that while Dock5...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18820033
DOI: 10.1073/pnas.0805546105
PMCID: PMC2563090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.PMID 18820033Read ↗

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes.Semantic proximity Read ↗

DOCK7 regulates WNT signaling and NMJ clustering in normal and DMD muscleSemantic proximity Read ↗

DOCK3 regulates normal skeletal muscle regeneration and glucose metabolismSemantic proximity Read ↗

Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge.Semantic proximity Read ↗

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.Semantic proximity Read ↗

SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion.Semantic proximity Read ↗

Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse.Semantic proximity Read ↗

PH domain of ELMO functions in trans to regulate Rac activation via Dock180.Semantic proximity Read ↗

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.Semantic proximity Read ↗

DOCK4, a GTPase activator, is disrupted during tumorigenesis.Semantic proximity Read ↗

Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.Semantic proximity Read ↗

Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity.Semantic proximity Read ↗

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