Article
Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains: possible involvement in systemic lupus erythematosus pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008
Tsukamoto Kazuyuki, Ohtsuji Mareki, Shiroiwa Wakana, Lin Qingshun, Nakamura Kazuhiro, Tsurui Hiromichi, Jiang Yi, Sudo Katsuko, Nishimura Hiroyuki, Shirai Toshikazu, Hirose Sachiko
Abstract excerpt
Both suppressive and promoting roles of NKT cells have been reported in the pathogenesis of systemic lupus erythematosus (SLE). Herein, we found that although New Zealand mice have normal frequencies of NKT cells, their in vitro potential to produce IL-4 and IFN-gamma in response to alpha-galactosylceramide was remarkably impaired in New Zealand Black (NZB) mice prone to mild SLE, while production was highly...
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