Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare loss of heterozygosity of the MTS1 and MTS2 tumor suppressor genes in differentiated human thyroid cancer.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Sept 1998

Schulte K M, Staudt S, Niederacher D, Finken-Eigen M, Köhrer K, Goretzki P E, Röher H D

Abstract excerpt

Loss of heterozygosity (LOH) of the MTS1 (p16) tumor suppressor gene has been reported to occur frequently in thyroid cancer cell lines. In order to determine the frequency of LOH for these multiple tumor suppressor genes, we used microsatellite markers IFNA and D9S171 to perform differential qua...

Topics

Adenoma
Alleles
Carcinoma, Papillary, Follicular
Carrier Proteins
Cell Cycle Proteins
Cell Differentiation
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
DNA, Neoplasm
DNA, Satellite

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Inhibitors

Gene Expression Regulation, Enzymologic

Gene Expression Regulation, Neoplastic

Genes, Tumor Suppressor

Heterozygote

Humans

Thyroid Neoplasms

Tumor Suppressor Proteins

Source

Identifiers

PMID: 9808321
DOI: 10.1055/s-2007-978930

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9808321-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare loss of heterozygosity of the MTS1 and MTS2 tumor suppressor genes in differentiated human thyroid cancer.PMID 9808321Read ↗

Infrequent mutations and no methylation of CDKN2A (P16/MTS1) and CDKN2B (p15/MTS2) in hepatocellular carcinoma in Taiwan.Semantic proximity Read ↗

Sporadic follicular thyroid tumors show loss of a 200-kb region in 11q13 without evidence for mutations in the MEN1 gene.Semantic proximity Read ↗

A frequent mutation/polymorphism in tumor suppressor gene INK4B (MTS-2) in papillary and medullary thyroid cancer.Semantic proximity Read ↗

Frequency of Mutation and Deletion of the Tumor Suppressor Gene Cdkn2a (Mts1/P16) in Hepatocellular Carcinoma From An Australian PopulationSemantic proximity Read ↗

Loss of heterozygosity at 19p13.2 and 2q21 in tumours from familial clusters of non-medullary thyroid carcinoma.Semantic proximity Read ↗

Gene alterations at the CDKN2A (p16/MTS1) locus in soft tissue tumors.Semantic proximity Read ↗

Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas.Semantic proximity Read ↗

Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer.Semantic proximity Read ↗

Studies of allelic loss in thyroid tumors reveal major differences in chromosomal instability between papillary and follicular carcinomas.Semantic proximity Read ↗

High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas.Semantic proximity Read ↗

Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors.Semantic proximity Read ↗

Elevated frequency of loss of heterozygosity in mammary tumors arising in mouse mammary tumor virus/neu transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.