Frequency of Mutation and Deletion of the Tumor Suppressor Gene Cdkn2a (Mts1/P16) in Hepatocellular Carcinoma From An Australian Population

doi:10.1002/hep.510250317

Article

Frequency of Mutation and Deletion of the Tumor Suppressor Gene Cdkn2a (Mts1/P16) in Hepatocellular Carcinoma From An Australian Population

1 Mar 1997

Abstract excerpt

The tumor suppressor gene CDKN2A (MTS1/p16), located on chromosome 9p21, is inactivated in a variety of tumors including melanomas and tumors of the biliary tract, pancreas, and stomach. The aim of the present study was to determine whether this gene is inactivated in hepatocellular carcinoma (HCC). Twenty-three primary HCCs and four HCC cell lines were examined. Loss of heterozygosity (LOH) analysis was...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.