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Article

Gene alterations at the CDKN2A (p16/MTS1) locus in soft tissue tumors.

International journal of oncology - 1 Aug 1998

Schneider-Stock R, Walter H, Haeckel C, Radig K, Rys J, Roessner A

Abstract excerpt

The CDKN2A gene (p16/MTS1) is a tumor suppressor that is frequently deleted, mutated, or inactivated by transcriptional silencing in certain tumor types and many tumor cell lines. We analyzed CDKN2A gene mutations and the frequency of loss of heterozygosity (LOH) at the CDKN2A locus in 135 soft tissue sarcomas. PCR-SSCP analysis of exons 1 and 2 of CDKN2A gene revealed only one missense mutation in codon 15 in a...

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PMID: 9664128
DOI: 10.3892/ijo.13.2.325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gene alterations at the CDKN2A (p16/MTS1) locus in soft tissue tumors.PMID 9664128Read ↗

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